Bcl-2/Bcl-xl inhibitor 1 16725 3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-[(pyridin-3-yl)methyl]piperazine-2-carboxamide

3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-[(pyridin-3-yl)methyl]piperazine-2-carboxamide

5-lactone is neutral

InChiKey: JOGKUKXHTYWRGZ-UHFFFAOYSA-N

Smiles: CC(=O)N[C@@H]1[C@@H](N)CC(=C[C@H]1OC(CC)CC)C(O)=O

Solubility: DMSO : ≥ 42 mg/mL (214

Bcl-2/Bcl-xl inhibitor 1 16725 3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-[(pyridin-3-yl)methyl]piperazine-2-carboxamideBcl 2 Bcl xl inhibitor 1 (compound 6) is a dual Bcl 2 and Bcl xl inhibitor with anti tumor activity, extracted from patent WO2018027097A1. Bcl 2 Bcl xl inhibitor 1 exhibits IC50 values of 2 nM and 5. 9 nM for Bcl 2 and Bcl xl, respectively. Product information CAS Number: 2180923 05 9 Molecular Weight: 882. 42 Formula: C45H48ClN7O8S Chemical Name: 4 (4 {[6 (4 chlorophenyl)spiro[3. 5]non 6 en 7 yl]methyl}piperazin 1 yl) N [4 ({[(2S) 1,4 dioxan 2