GPI-1046 - CAS# 186452-09-5 020 WY-14643 also causes increased SIRT1

WY-14643 also causes increased SIRT1 activity in Sham and ischemia-reperfusion (IR) group

543906-09-8

4-dimethoxybenzamido)-4

InChiKey: DWJUZHMCPBPNFH-UHFFFAOYSA-N

InChi: InChI=1S/C13H9F3N2O2/c14-13(15

GPI-1046 - CAS# 186452-09-5 020 WY-14643 also causes increased SIRT1GPI 1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc core. GPI 1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models. GPI 1046 readily crosses the blood brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with