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Chemical Name: GW806742X
Smiles: O=C1NN=C2NC(CN3CC4=CC=CC=C4C3)=NC3=CC=CC1=C32
Orringer MB
InChi: InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9
Formula: C23H26N6O10S2
Volasertib Catalog No.:M10873-10 Chemical Name: GW806742XVolasertib, also known as BI 6727, is a dihydropteridinone Polo like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. BI 6727 selectively inhibits Plk1, inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. BI 6727 is highly potent (enzyme IC(50) = 0. 87 nmol L, EC(50) = 11 37 nmol L on a panel of cancer cell
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