(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 Biochem Biophys Res Commun

Biochem Biophys Res Commun

J Clin Virol

It also has inhibitory activities against HDAC 6

PARP-2 and other ARDT enzymes

Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors

(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 Biochem Biophys Res CommunMutations, CAS No. 103404 90 6, in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, such as leukemia and glioma, and result in overproduction of the (R) enantiomer of 2 hydroxyglutarate [(R) 2 HG]. Elucidation of the role of IDH mutations and (R) 2 HG in leukemogenesis has been hampered by a lack of appropriate cell based models. It has been recently reported that a canonical IDH1 mutant, IDH1