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Formula: C43H51N3O11
Chemical Name: (E)-N-benzyl-2-cyano-3-(3
CAS Number: 29477-83-6
suggesting rolapitant is a viable clinical candidate for this indication
Morbidelli L
CB-839 H 298 Formula: C43H51N3O11Telaglenastat, also known as CB 839, an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Telaglenastat selectively and irreversibly inhibits glutaminase. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the
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