Ald-Ph-amido-PEG11-NH-Boc 5420 Intra-BLA administration of MS21570 leads

Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test

which is accompanied by reduction in mitochondrial content with subsequent suppression of genes which promote mitochondrial biosynthesis

Smiles: CC(C)C1N=C(ON=1)C1CCN(CC1)C1=NC=NC(NC2=CC=C(C=C2F)S(C)(=O)=O)=C1N(=O)=O

Release of 7-HC

a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity

Ald-Ph-amido-PEG11-NH-Boc 5420 Intra-BLA administration of MS21570 leadsAld Ph amido PEG11 NH Boc is a non cleavable 11 unit PEG ADC linker used in the synthesis of antibody drug conjugates (ADCs). Product information CAS Number: 1245813 70 0 Molecular Weight: 776. 91 Formula: C37H64N2O15 Chemical Name: tert butyl N {35 [(4 formylphenyl)formamido] 3,6,9,12,15,18,21,24,27,30,33 undecaoxapentatriacontan 1 yl}carbamate Smiles: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C1C=CC(=CC=1)C=O InChiKey: RDSLXILMKJRJBU