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J Hematol Oncol
PubMed PMID: 22713795
Christophe H
Russell JL
is a c-Myc/Max interaction inhibitor
(Z)-4-Hydroxytamoxifen - CRISPR Editing Enhancer. CAS# 68047-06-3 0124 J Hematol Oncol(Z) 4 Hydroxytamoxifen (also called 4 OH TAM), CAS No. 68047 06 3, was previously characterized as an Estrogen Receptor antagonist and now found to improve genome editing specificity in CRISPR mediated gene editing. It can activate intein linked inactive Cas9, reducing off target. Such system has ~25 fold higher specificity than wtCas9. (Z) 4 Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency
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