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It dose-dependently reduces IRE1α kinase autophosphorylation in vitro with IC50 ~0
9 μmol/kg/day
Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line
3 A resolution from crystals perfectly twinned by hemihedry
Front Physiol
BPTES - CAS# 314045-39-1 size:10mg solid It dose-dependently reduces IRE1α kinaseBPTES, CAS No. 314045 39 1, is a selective inhibitor of Glutaminase GLS1 (KGA), which is found in the kidney and brain, and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines. BPTES has a K(i) of approx. 3 microM. BPTES inhibits the allosteric activation caused by phosphate binding and promotes the formation of an inactive complex. Product information CAS Number: 314045 39 1 Molecular Weight: 524. 68 Formula:
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