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2 μM for VPS4B and p97
as well as a rapid clearance in male Sprague-Dawley rats
thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins
currently being investigated in a single-agent Phase 1/2 clinical trial in patients with advanced solid tumors and lymphomas
24)/b19-11+
CL2A Abd-7 2 μM for VPS4B andCL2A is a claevable complicated PEG8 and triazole containing PABC peptide mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker. Product information CAS Number: 2616704 22 2 Molecular Weight: 1062. 21 Formula: C50H79N9O16 Chemical Name: N [(1 {26 [2 ({[(1S) 5 amino 1 {[4
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