Boc-C1-PEG3-C4-OBn sanib Diphosphate Flavopiridol also decreases the overall

Flavopiridol also decreases the overall RNA polymerase II level

CAS Number: 931398-72-0

InChi: InChI=1S/C13H14N2O4S2/c16-11-6-7-12(17)15(11)19-13(18)5-3-9-20-21-10-4-1-2-8-14-10/h1-2

PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4

Chemical Name: (E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide

Boc-C1-PEG3-C4-OBn sanib Diphosphate Flavopiridol also decreases the overallBoc C1 PEG3 C4 OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc C1 PEG3 C4 OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader 1 (HY 125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin proteasome system to selectively degrade target