InChi: InChI=1S/C50H71N15O11S/c1-77-21-18-33(52)43(69)61-36(16-17-42(67)68)46(72)65-40(24-31-26-55-28-59-31)48(74)63-38(22-29-10-3-2-4-11-29)47(73)62-35(15-9-20-56-50(53)54)45(71)64-39(23-30-25-57-34-13-6-5-12-32(30)34)44(70)58-27-41(66)60-37(49(75)76)14-7-8-19-51/h2-6
inhibits IL-6 production with an EC50 of 16
Sanofi announced that it had ended development of the drug candidate after poor performance in a Phase III clinical trial
and in the p53 mutant SW620 cells and human breast cancer cell line
Dexamethasone regulates several transcription factors
2-Amino-1, 3-bis(carboxylethoxy)propane ne diol-heptyldioxolane-d15 InChi: InChI=1S/C50H71N15O11S/c1-77-21-18-33(52)43(69)61-36(16-17-42(67)68)46(72)65-40(24-31-26-55-28-59-31)48(74)63-38(22-29-10-3-2-4-11-29)47(73)62-35(15-9-20-56-50(53)54)45(71)64-39(23-30-25-57-34-13-6-5-12-32(30)34)44(70)58-27-41(66)60-37(49(75)76)14-7-8-19-51/h2-62 Amino 13 bis(carboxylethoxy)propane is a PEG based PROTAC linker that can be used in the synthesis of PROTACs. Product information CAS Number: 1020112 73 5 Molecular Weight: 235. 23 Formula: C9H17NO6 Chemical Name: 3 [2 amino 3 (2 carboxyethoxy)propoxy]propanoic acid Smiles: NC(COCCC(O)=O)COCCC(O)=O InChiKey: HWQYUSUCQZDSSK UHFFFAOYSA N InChi: InChI=1S C9H17NO6 c10 7(5 15 3 1 8(11)12)6 16 4 2 9(13)14 h7H,1 6,10H2,(H,11,12)(H,13,14) Technical Data
