VU0364572 (trifluoroacetate salt) 247egeline InChi: InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26

InChi: InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26

91(20):13080-13087

PLpro inhibitor display significant antiviral activity with EC50 values of 13

24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment

whereas the CYM-5520 is an agonist with an EC50 of 1

VU0364572 (trifluoroacetate salt) 247egeline InChi: InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26IC50: 477 172 nM VU0364572 is a M1 agonist. Alzheimer's disease (AD) is the leading cause of dementia worldwide, and no disease modifying therapy is availables. Selective M1 muscarinic acetylcholine receptor activation is an attractive mechanism for AD therapy since M1 mediates key effects on cognition, memory, and behavior and has potential for disease modifying effects on A formation and tau phosphorylation. In vitro: Previous study found that