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Solubility: DMSO : 25 mg/mL (99
18-dimethoxy-17-(3
43-29(45)22(3)4)31(47)41-27(10-9-21-40-33(38)39)30(46)44-35(19-7-8-20-35)32(48)42-28(23-11-15-25(36)16-12-23)24-13-17-26(37)18-14-24/h11-18
PMID: 22715131
and BTZ043 for this strain were 9
VER-49009 Size:Solid 10 mg Solubility: DMSO : 25 mg/mLVER 49009 is a potent HSP90 inhibitor. VER 49009 inhibits Hsp90 with an IC50 value of 47 nM. VER 49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER 49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C RAF, B RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. Product information CAS Number: 558640 51
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