HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 InChi: InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H

InChi: InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H

22(8):2968-72

Chemical Name: 2-(1

Epub 2006 Jun 9

Rapamycin is usually used at 1 µM final concentration in vitro and in cellular assays

HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 InChi: InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8HHTH 01 015, CAS No. 1613724 42 7, is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH 01 015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound healing assay to a similar extent as NUAK1 knockout. HTH 01 015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout