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Chemical Name: N2-(4-fluorophenyl)-N4-phenyl-N6-[(pyrimidin-2-yl)methyl]-1
Formula: C16H22ClNO3
In neuroblastoma (NB) cell lines
Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level
06 mM and Ki'=0
Almonertinib hydrochloride Catalog No.:M17886-C Chemical Name: N2-(4-fluorophenyl)-N4-phenyl-N6-[(pyrimidin-2-yl)methyl]-1Almonertinib (HS 10296) hydrochloride is an orally available, irreversible, third generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M L858R and T790M Del19 (IC50: 0. 37, 0. 29 and 0. 21 nM, respectively), and is less effective against wild type (3. 39 nM). Almonertinib hydrochloride is used for the research
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