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whereas an inactive CFTRinh172 analog does not inhibit fluid secretion
EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity
Harrington B
Solubility: DMSO 80 mg/mL (201
Formula: C15H24N4O6S2
17-AAG Hydrochloride zithromycin whereas an inactive CFTRinh172 analog17 AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100 fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild type androgen receptor (AR), leading to the RB dependent G1 growth arrest of prostate cancer cells. It has the ability to induce