![CK-636 - CAS# 442632-72-6 434 3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/CK-636_structure.gif?v=1742663280)
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3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
InChi: InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7
17(5):877-86
having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis
PubMed PMID: 15215558
CK-636 - CAS# 442632-72-6 434 3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acidCK 636, CAS No. 442632 72 6, is a Arp2 3 complex inhibitor. CK 636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK 636 inserts into the hydrophobic core of Arp3 and alters its conformation. Polymerization of actin filaments directed by the actin related protein (Arp)2 3 complex supports many types of cellular movements. CK 636 may be a powerful tool compound for studying the Arp2 3
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