Siramesine Hydrochloride Catalog No.:M8962-10 Inhibition was competitive with respect

Inhibition was competitive with respect to ATP (Ki = 95 nM)

with low cytotoxicity (SI =2088)

Delpazolid

Chemical Name: 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole

TAK-875 is currently in clinical trials for the treatment of type 2 diabetes mellitus

Siramesine Hydrochloride Catalog No.:M8962-10 Inhibition was competitive with respectSiramesine, also known as Lu 28 179, is a potent sigma 2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress. Product information CAS Number: 224177 60 0 Molecular Weight: 491. 04 Formula: C30H32ClFN2O Synonym: Lu 28 179 hydrochloride