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(2005) Cardiovasc Drug Rev
An introductory study
PubMed PMID: 25515519
33(11):12760-12767
Similarly in the proliferation assay
Lometrexol hydrate - CAS# 1435784-14-7 Size:2mg solid (2005) Cardiovasc Drug RevLometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine
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