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Chemical Name: N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3
US/2008/0226747
9-fold more potent for JNK1 inhibition than JNK2 in a cell-based model
A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate
PCI-32765 Racemate is oral effective in vivo
Vorinostat olnaftate Chemical Name: N-(2-(4-amino-3-(p-tolyl)-1H-pyrazolo[3Vorinostat, also known as suberanilohydroxamic acid, MK 0683 and SAHA, is a potent and selective inhibitor of histone deacetylases (HDACs). Vorinostat has been shown to bind to the active site of histone deacetylases and act as a chelator for Zinc ions also found in the active site of histone deacetylases. Vorinostat's inhibition of histone deacetylases results in the accumulation of acetylated histones and acetylated proteins, including transcription