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Rat hepatocarcinoma cells (FAO) stimulated by fetal calf serum (FCS) exhibits a significant proportion in S phase (32
Smiles: COC1=CC=CC=C1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C
consistent with an essential role for HECT ligase activity in mammalian cells
Binding studies indicate that it has no effect on monoamine uptake and no affinity for α
in patients with advanced solid malignancies
Bedaquiline Catalog No.:M8161-2 Rat hepatocarcinoma cells (FAO) stimulatedBedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria. It is the first member of a new class of drugs called the diarylquinolines.
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