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GW627368 (GW627368X) appears to bind to human prostanoid TP receptors but not the TP receptors of other species
At the molecular level
InChi: InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16
BT474 and SKBR3 cell lines
specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1)
AP 1903 - CAS# 195514-63-7 size:2mg solid GW627368 (GW627368X) appears to bindAP 1903, CAS No. 195514 63 7, also known as Rimiducid, is a lipid permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild type FKBP12 with 1000 fold lower affinity. This agent is used to homodimerize the Fv containing drug binding domains of genetically engineered receptors such as the iCD40