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FM-381 shows an apparent EC50 of 100 nM in a dose dependent BRET assay and blocks IL2 stimulated (JAK3/JAK1 dependent) STAT5 phosphorylation at 100 nM
increases haemoglobin S (HbS) affinity for oxygen
It serves as a useful chemical tool to further validate and develop novel treatments of osteoporosis via promoting bone formation
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal
SPR741 TFA Size:Contact [email protected] for quotation FM-381 shows an apparent EC50SPR741 TFA (NAB741 TFA) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 TFA increases the permeability of the outer membrane of Gram negative bacteria and is used to treat severe Gram negative bacteria infections. SPR741 TFA inhibits multidrug resistant Gram negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 TFA. Product information Molecular Weight: