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Therefore KDM5-C70 was developed as a pro-drug
118(4):1289-1297
with IC50s of 19 and 51 nM for ROCK2 and ROCK1
It is used to treat certain patients with breast cancer and liposarcoma
Crenolanib treatment does not increase the cell surface expression of ABCB1
FTI-277 Hydrochloride Size:Solid 10 mg Therefore KDM5-C70 was developed asFTI 277 is a peptide mimetic of the COOH terminal Cys Val Ile Met of K Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI 277, the methyl ester derivative of FTI 276, was extremely potent (IC50 = 100 nM) at inhibiting H Ras, but not the geranylgeranylated Rap1A processing in whole cells. Product information CAS Number: 180977 34 8 Molecular
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