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Colo205-R cells (IC50: >10 μM) are >300-fold more resistant to Ingenol Mebutate than parental Colo205-S cells
[Epub ahead of print] PubMed PMID: 32029439
and inhibitors targeting this pathway could prevent resistance
Smiles: CC(=O)N[C@H](COC)C(=O)NCC1C=CC=CC=1
CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7
BMS-378806 Catalog No.:M10727-10 Colo205-R cells (IC50: >10 μM)BMS 378806 is a small molecule that inhibits the first step of HIV 1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (Kd= 21. 1 nM; Ki = 24. 9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. Product information CAS Number: 357263 13 9 Molecular Weight: 406. 43 Formula: C22H22N4O4 Chemical
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