INCB-057643 430niporide hydrochloride Smiles: COC1=NC(=CC=C1CNCCNC(C)=O)OCC1C=CC=C(C2=CC=CC=C2)C=1C

Smiles: COC1=NC(=CC=C1CNCCNC(C)=O)OCC1C=CC=C(C2=CC=CC=C2)C=1C

interleukin (IL)-1β

InChiKey: VSGNGLJPOGUDON-UHFFFAOYSA-N

11016) in isolated rat peritoneal mast cells (IC50s = 0

2nM for I-IP-10 and I-ITAC

INCB-057643 430niporide hydrochloride Smiles: COC1=NC(=CC=C1CNCCNC(C)=O)OCC1C=CC=C(C2=CC=CC=C2)C=1CINCB 057643 is a novel, orally bioavailable BET inhibitor. Product information CAS Number: 1820889 23 3 Molecular Weight: 415. 46 Formula: C20H21N3O5S Chemical Name: 6 methanesulfonyl 2,2,4 trimethyl 8 {6 methyl 7 oxo 1H,6H,7H pyrrolo[2,3 c]pyridin 4 yl} 3,4 dihydro 2H 1,4 benzoxazin 3 one Smiles: CN1C=C(C2C=CNC=2C1=O)C1C=C(C=C2C=1OC(C)(C)C(=O)N2C)S(C)(=O)=O InChiKey: VZSAMEOETVNDQH UHFFFAOYSA N InChi: InChI=1S C20H21N3O5S c1 20(2)19(25)23(4)15 9