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and human ether-a go-go-related gene (hERG)
Formula: C23H18ClF2N3O3S
as shown by the decreased levels of chymotrypsin-like activity and increased accumulation of ubiquitinated proteins in LNCaP cells
is a potent and selective bone morphogenetic protein receptor (BMP) inhibitor that inhibits ALK1 and ALK2 with IC50 values of 46 and 32 nM
InChiKey: WSMXAUJFLWRPNT-DIVCQZSQSA-N
K-7174 dihydrochloride iophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1 3-dione and human ether-a go-go-related geneK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product
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