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4]-oxaazacyclohentriacontine-1
Solubility: DMSO and water up to 100 mM
23246–23254
1'-biphenyl]-2-carbonitrile
Romagnoli R
PIK-III - CAS# 1383716-40-2 6053 4]-oxaazacyclohentriacontine-1PIK III, also known as VPS34 IN2, CAS No. 1383716 40 2, is a VPS34 inhibitor which blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. PIK III binds a unique hydrophobic pocket not present in related kinases such as PI(3)K. PIK III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. . Product information CAS Number: 1383716 40 2 Molecular
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