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Combretastatin A-1 (1-4 mg/kg
CC1C2NC3C=CC=CC=3C=2C(C)=C2C=NC=CC=12
Smiles: CC(=O)N(CC)C1=CC(=CC=C1)C1=CC=NC2=C(C=NN12)C#N
CAS Number: 82611-88-9
is a known MAPK inhibitor
Z-DQMD-FMK 17517 Combretastatin A-1 (1-4 mg/kgInhibition of caspase 3 processing by Z DQMD FMK (Z Asp(OMe) Gln Met Asp(OMe) fluoromethylketone) did not restore cell number in the zinc deficient group, but resulted in processing of full length PKC to a 56 kDa fragment1. The inhibitory effect of specific caspase inhibitors (Z DQMD FMK, Z IETD FMK and Z LEHD FMK) suggests that the MG132 induced apoptotic cell death and depletion of GSH in SCLC cells are mediated by both activation of caspase 8 and
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