NV-5138 C AR Degrader-4 TFA Chemical Name: 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}-1

Chemical Name: 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}-1

is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1

57(10):4213-38

3 µM) and a TGFβ receptor inhibitor (SB431542

Remodelin was used at 1-10 µM in vitro and cellular assays

NV-5138 C AR Degrader-4 TFA Chemical Name: 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}-1NV 5138 is an orally and centrally active small molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal