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CNQX causes a complete blockade at a dose of 0
MI-2 was nontoxic to mice
PubMed PMID: 24900311
The IC50 for CYP3A4/5 and for CYP2C19 is >50 μM
It has excellent selectivity against human DUBs
TRIM24-C34 - BRPF1B/TRIM24 Dual Inhibitor. CAS# 1242907-48-7 ry of Histone Demethylase CNQX causes a complete blockadeTRIM24 C34, CAS No. 1242907 48 7, is a potent, selective and cell permeable BRPF1B and TRIM24 dual inhibitor. TRIM24 C34 binds to bromodomain BRPF1B with a Kd of 137 nM, and the transcriptional regulator TRIM24 (also an E3 ubiquitin ligase) with a Kd of 222 nM. It has very good selectivity against other 45 bromodomains. Cellular activity of TRIM24 C34 was demonstrated using FRAP assays as well as cell viability data. It showed no significant
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