Lotilaner 085727 3-benzodioxol-5-yloxy)pyridin-3-yl]formamido}methyl)-3-fluorophenoxy]propanoic acid

3-benzodioxol-5-yloxy)pyridin-3-yl]formamido}methyl)-3-fluorophenoxy]propanoic acid

InChi: InChI=1S/C18H17FO2S/c1-22(20

In a pharmacodynamic experiment following chronic oral dosing (25 mg/kg b

9 μM at 24 h and 48 h

but does not activate ASK1/JNK in Ramos cells

Lotilaner 085727 3-benzodioxol-5-yloxy)pyridin-3-yl]formamido}methyl)-3-fluorophenoxy]propanoic acidLotilaner is a parasiticide, acts as a potent non competitive antagonist of insects GABACl receptors, with an IC50 of 23. 84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor. Product information CAS Number: 1369852 71 0 Molecular Weight: 596. 76 Formula: C20H14Cl3F6N3O3S Chemical Name: 2 ({3 methyl 5 [(5S) 5 (3,4,5 trichlorophenyl) 5 (trifluoromethyl) 4,5 dihydro 1,2 oxazol 3 yl]thiophen 2 yl}formamido) N (2,2,2