OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S and induces p53-dependent apoptosis in

and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines

is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM

GNF4877 and its analog GNF7156 are the good chemical tools to support the feasibility of treating diabetes with an oral therapy to restore β-cell mass

demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat

Smiles: C[C@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1C=CC(=CC=1)OC)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)[C@]1(C)CO1

OF-1 - BRPF Bromodomain Inhibitor. CAS# 919973-83-4 Catalog No.:M60222-10S and induces p53-dependent apoptosis inOF 1, CAS No. 919973 83 4, is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2. 4 mM (ITC). It has general >100 fold selectivity against other bromodomains (39 fold selectivity over BRD4). OF 1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 M and also