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InChi: InChI=1S/C19H19ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8
Sacubitril (AHU-377) is converted by enzymatic cleavage of the ethyl ester into the active neprilysin inhibiting metabolite LBQ657
Unlike AEA
Chemical Name: N-[(2R)-butan-2-yl]-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
1 μM) exhibits a concentration‐dependent inhibition on VEGF‐induced (40 ng/mL) phosphorylation of VEGFR2 and its downstream signaling molecules ERK1/2
2-Keto Crizotinib misone InChi: InChI=1S/C19H19ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-82 Keto Crizotinib (PF 06260182) is an active lactam metabolite of crizotinib. Product information CAS Number: 1415558 82 5 Molecular Weight: 464. 32 Formula: C21H20Cl2FN5O2 Chemical Name: 4 (4 {6 amino 5 [(1R) 1 (2,6 dichloro 3 fluorophenyl)ethoxy]pyridin 3 yl} 1H pyrazol 1 yl)piperidin 2 one Smiles: C[C@@H](OC1C=C(C=NC=1N)C1C=NN(C=1)C1CCNC(=O)C1)C1=C(Cl)C(F)=CC=C1Cl InChiKey: KLXFBZLBBBMWAI YNODCEANSA N InChi: InChI=1S C21H20Cl2FN5O2 c1 11(19 15(22)2