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and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay
11(3):1039-1044
InChiKey: UJKPHYRXOLRVJJ-AMPAVEGJSA-N
Strangman NM
high affinity histamine H1-receptor-selective antagonist with Ki of 1
Bendamustine Hydrochloride ntan Hydrochloride and also inhibits telomerase activityBendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and
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