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3-d]pyrimidin-6-yl]-2-chloroethan-1-one
InChi: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H
271(3):1483-8
Formula: C25H26FN3O2
CAS Number: 1911564-39-0
CMLD-2 - CAS# 958843-91-9 Demethylase 3-d]pyrimidin-6-yl]-2-chloroethan-1-oneCMLD 2, an inhibitor of HuR ARE interaction, competitively binds HuR protein disrupting its interaction with adenine uridine rich elements (ARE) containing mRNAs (Ki=350 nM). CMLD 2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation. Product information CAS Number: 958843 91 9
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