SB-612111 Catalog No.:M23908-C It induces degradation of EGFR

It induces degradation of EGFR in OVCAR8 cells

2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18

PD153035 not only blocks cell growth via inhibition of EGFR

CAS Number: 2360530-43-2

with IC50 of 3800 nM

SB-612111 Catalog No.:M23908-C It induces degradation of EGFRSB 612111 is a novel and potent opiate receptor like orphan receptor (ORL 1) antagonist with a high affinity for hORL 1 (Ki=0. 33 nM). SB 612111 exhibits selectivity for , and receptors with Ki values of 57. 6 nM, 160. 5 nM and 2109 nM, respecticely. SB 612111 effectively antagonizes the pronociceptive action of Nociceptin (HY P0183) in an acute pain model. Product information CAS Number: 371980 98 2 Molecular Weight: 454. 86 Formula: C24H30Cl3NO