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6 Suppl 3:107-12
M5 receptors
InChiKey: YYLKKYCXAOBSRM-JXMROGBWSA-N
broad-spectrum oral fluoroquinolone that is very active against many Gram-positive
(2012) Journal of Medicinal Chemistry
ELN-441958 Catalog No.:M21309-C 6 Suppl 3:107-12ELN 441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR 90 cells with Ki of 0. 26 nM. ELN 441958 is highly selective for B1 over B2 receptors, and >500 2000 fold selective for the B1 over opioid receptor. IC50 value: 0. 26 nM (Ki)Target: B1 Receptorin vitro: ELN 441958 is a novel small molecule bradykinin B1 receptor antagonist, based on the inhibition of agonist induced increases in
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