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186(7):3986-96
1446502-11-9
BRD3 and BRD4 with IC50 of 10-19 nM
It can also suppress growth of a multiple myeloma (MM) cell line and reduces the growth of MM tumor xenografts in mice
and has weaker activity against monoamine oxidase proteins MAO-A and MAO-B with IC50 ~0
NI-57 - BRPF Bromodomain Inhibitor. CAS# 1883548-89-7 Catalog No.:M60279-10S 186(7):3986-96NI 57, CAS No. 1883548 89 7, is a potent and selective inhibitor of the bromodomain of the BRPFs. It binds to BRPF1B with a KD of 31 nM (ITC), to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC). NI 57 is very selective against other non Class IV bromodomains, including the BETs, has minimum 32 fold selectivity against BRD9. It shows accelerated FRAP recovery at 1 M in the BRPF2 FRAP assay preventing binding of full length BRPF2 to