PROTAC BRD2/BRD4 degrader-1 in C 3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1

3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1

Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (−CH-11)

Smiles: C[C@H]1CC=CC(=O)[C@@H](O)[C@@H](O)C[C@H]2O[C@@H]2C2=CC(=CC(O)=C2C(=O)O1)OC |c:3|

13 μM for G9a

Simultaneous detection of hepatitis C virus core antigen and antibodies in Saudi drug users using a novel assay

PROTAC BRD2/BRD4 degrader-1 in C 3-dihydro-2H-benzo[e]indol-2-ylidene)penta-1PROTAC BRD2 BRD4 degrader 1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader. PROTAC BRD2 BRD4 degrader 1 rapidly induces reversible, long lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2 BRD4 degrader 1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon (CRBN) cullin 4A. Product information