Fostriecin sodium salt Catalog No.:M22411-C Shikonin is a major component

Shikonin is a major component of a Chinese herbal medicine named zicao

3S)-2-hydroxy-3-[(2E)-2-methylbut-2-enamido]-3-phenylpropanoyl]oxy}-10

Phoyunnanin E decreases cancer cell invasion

11(10):738-46

InChiKey: AXMBOMODZLJDKX-PKNBQFBNSA-N

Fostriecin sodium salt Catalog No.:M22411-C Shikonin is a major componentIC50: Inhibit protein phosphatase types 2A (PP2A) and 4 (PP4) intensively with an IC50 of 1. 5 nM and 3 nM respectively. Inhibit topoisomerase II (Topo II) and protein phosphatase type 1 (PP1) slightly with an IC50 of 40 M and 131 M respectively. Fostriecin, an anti tumor antibiotic originates from Streptomyces pulveraceus, is considered to exert its activity by interfering the reversible phosphorylation of several important proteins in cell cycle.