LXR-623 epridil HCl Cardamonin inhibits activation of the

Cardamonin inhibits activation of the NF-κB pathway

CAS Number: 364622-82-2

also known as OPC-34712

is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties

also known as TRO-19622 and RG6083

LXR-623 epridil HCl Cardamonin inhibits activation of theLXR623, also known as WAY 252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR( ) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY 252623 significantly reduced total (50 55%) and LDL cholesterol (LDLc) (70 77%) in a time and dose