VLX1570 - CAS# 1431280-51-1 288 CCO/N=C(/C1N=C(NP(O)(O)=O)SN=1)\C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3C=C[N+](C)=CC=3)=C(C(O)=O)N2C1=O

CCO/N=C(/C1N=C(NP(O)(O)=O)SN=1)\C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3C=C[N+](C)=CC=3)=C(C(O)=O)N2C1=O

2018 Jan 2

Chemical Name: (Z)-4-(4-((5-(4

21(22):7107-17

IP administration of SR10067 was used at 30 mg/kg to mice

VLX1570 - CAS# 1431280-51-1 288 CCO/N=C(/C1N=C(NP(O)(O)=O)SN=1)\C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3C=C[N+](C)=CC=3)=C(C(O)=O)N2C1=OVLX1570, CAS No. 1431280 51 1, is an inhibitor of the 19S proteasome specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly