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8-tetrahydro-[1
Epub 2010 Jul 31
and c-Met-T1010I with IC50 of 3
85(3):429-40
Treshkur T
DCC-2036 t N-oxide 8-tetrahydro-[1DCC 2036, is an orally bioavailable small molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor DCC 2036 binds to and inhibits the Bcr Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand dependent and ligand independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine
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