NGB 2904 hydrochloride nedioic Acid Smiles: OC(C1C=CC(=CC=1)N(CC(F)(F)F)S(=O)(=O)C1C=CC=CC=1)(C(F)(F)F)C(F)(F)F

Smiles: OC(C1C=CC(=CC=1)N(CC(F)(F)F)S(=O)(=O)C1C=CC=CC=1)(C(F)(F)F)C(F)(F)F

NC1NC(=O)C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C=2N=1

7)/b3-2+/i1D3

6(2):192-7

InChi: InChI=1S/C19H20O10/c20-6-11-15(25)17(27)18(28)19(29-11)13-10(23)5-9(22)12(16(13)26)14(24)7-1-3-8(21)4-2-7/h1-5

NGB 2904 hydrochloride nedioic Acid Smiles: OC(C1C=CC(=CC=1)N(CC(F)(F)F)S(=O)(=O)C1C=CC=CC=1)(C(F)(F)F)C(F)(F)FNGB 2904 hydrochloride is a potent, selective, orally active and brain penetrated antagonist of dopamine D3 receptor, with a Ki of 1. 4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5 HT2, 1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine induced