GSK J5 tan (medoxomil monopotassium) 14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy}-4-oxobut-2-enoic acid

14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy}-4-oxobut-2-enoic acid

CAS Number: 2320258-95-3

Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II

SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0

The time for 50% of the P450 2B1 to become inactivated at saturating concentrations of 2-phenyl-2-(1-piperidinyl)propane was ~2

GSK J5 tan (medoxomil monopotassium) 14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy}-4-oxobut-2-enoic acidThe histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.,. GSK J4 is a cell permeable prodrug which is modified by intracellular esterases to give GSK J1, an inhibitor of JMJD3. GSK J5 is a pyridine regio isomer of GSK J4. Like GSK J4, this isomer is cell permeable and hydrolyzed to a free base. 3 However, the free base is a