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InChiKey: UFPINDDCTUCUSA-ABGUIGEDSA-N
PubMed PMID: 25420519
Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia
Formula: C53H83NO14
1222998-36-8
PROTAC Sirt2 Degrader-1 0259 InChiKey: UFPINDDCTUCUSA-ABGUIGEDSA-NSirt2 PROTAC 1 is a SirReal based PROTAC, inducing isotype selective Sirt2 degradation. PROTAC Sirt2 Degrader 1 is composed of a highly potent and isotype selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader 1 shows an IC50 of 0. 25 M for Sirt2, with no effect on Sirt1 Sirt3 (IC50s>100 M). Product information CAS Number: 2098487 75 1 Molecular Weight: 852. 94 Formula: C40H40N10O8S2
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