ML-SI3 hyl)anthraquinone 1'-biphenyl]-3-yl}propanoic acid

1'-biphenyl]-3-yl}propanoic acid

with a pIC50 of 0

6-tetrahydroxy-4-{[(2S

Binding IC50: 1

treatment with up to 5 mg/kg Cobimetinib (GDC-0973) lead to moderate TGI and at 10 mg/kg approaches tumor stasis

ML-SI3 hyl)anthraquinone 1'-biphenyl]-3-yl}propanoic acidML SI3 is a chemical compound which acts as an "antagonist" (i. e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Product information CAS Number: 891016 02 7 Molecular Weight: 429. 58 Formula: