AT7867 dihydrochloride Catalog No.:M9924-2 Vacuolin-1 inhibits autophagy by impairing

Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition

It induces cell death in a BAX-dependent fashion

Smiles: CCOC1C=CC(CC2=CC(=CC=C2Cl)[C@@]23O[C@](CO2)(CO)[C@@H](O)[C@H](O)[C@H]3O)=CC=1

is an autophagy inhibitor

L'Allier PL

AT7867 dihydrochloride Catalog No.:M9924-2 Vacuolin-1 inhibits autophagy by impairingAT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. This ATP competitive small molecule potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta and S6 ribosomal protein phosphorylation, and also causes growth inhibition in a range of human cancer cell lines as a single agent. Product information CAS Number: 1431697 86 7