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PLX-4720 - CAS# 918505-84-7 60209 which inhibits degranulation downstream of

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Description

which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells

but activates only the α7 to any significant extent

Treatment of two mouse models of obesity/diabetes with WWL113 ameliorates multiple features of metabolic syndrome

Novantrone

18(9):2502-14

PLX-4720 - CAS# 918505-84-7 60209 which inhibits degranulation downstream ofPLX 4720, CAS No. 918505 84 7, is a 7 azaindole derivative that inhibits B Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX 4720 preferentially inhibits the active B Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. Product information CAS Number: 918505 84 7

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